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Matrix metalloproteinase-10 is upregulated by thrombin in endothelial cells and increased in patients with enhanced thrombin generation

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Healthcare professionals continue to monitor for any emerging safety signals, and patients are encouraged to report any unusual symptoms through the Yellow Card scheme

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Your weight loss has plateaued: If your weight loss stalls for several weeks despite consistent diet changed and increased physical activity along with your medication, a higher dose may be needed to re-stimulate your metabolism and appetite suppression

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