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Source: Employer Benefit Research Institute April 16, 2026 GLP-1 medications for obesity carry a well-documented discontinuation problem, and stopping them typically means regaining weight and the return of cardiometabolic risk factors

Exceeding the recommended dosage will not speed up results and may lead to discomfort or digestive issues

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Large cardiovascular outcome trials with liraglutide [40], semaglutide [41], and dulaglutide [42] have shown reductions in adverse cardiovascular events and cardiovascular mortality, while the SELECT trial demonstrated a reduction in heart failure with semaglutide [43]