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The DNA-bound PARPs, such as PARP1-3, can attach the mono-ADP-ribose (MAR) or poly-ADP-ribose (PAR) moieties directly to the DNA breaks
Simultaneously, released Cu 2+ causes redox reaction with the intracellular overexpressed GSH, and subsequently produces Cu + for initiation of Fenton-like reactions, resulting in the production of OH and robust anticancer therapy
Genetics play a role in how your body responds: variants in the GLP1R gene (like rs6923761) influence how sensitive your intestinal cells are to the medication
Each signature was queried against the CMap using the algorithm described by Lamb et al .[13]
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