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A review by Cardinali highlights melatonins potential in counteracting neurodegeneration and frailty in the elderly, noting melatonins excellent safety profile and low toxicity even at high doses ( Melatonin supplementation in older adults must be timed correctly to avoid phase shifts that could worsen circadian timing if misused
of Facilities: 174 (estimated) No
Supplementary Figure S3)
Mean pulse rate showed a decrease of approximately 5 beats per minute lower at the end of treatment compared to baseline for all cohorts compared to placebo
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