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Since autophagy is one of the main players in the degradation of damaged organelles and protein aggregates to maintain cellular homeostasis and is also tightly connected to other essential cellular signaling pathways like nutrient sensing or cell death, deregulation of this pathway can have severe consequences in cancer development and progression (199)

Anemia - 0.2 mg per day every other day

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Figure 2 3 Central nervous system clinical manifestations 3.1 Chronic fatigue Multiple studies have shown that chronic fatigue is the underlying symptom in L-C19 (35)