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Discovery of novel oestrogen receptor alpha agonists and antagonists by screening a revisited previleged structure moiety for nuclear receptors

Sci Rep 10:1165

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An assessment of the expression of key OXPHOS subunit proteins (succinate dehydrogenase B [SDHB], Ubiquinol-Cytochrome C Reductase Core Protein 2 [UQCRC2], Mitochondrially Encoded Cytochrome C Oxidase I [MTCO1], ATP synthase subunit alpha of complex V [vATP5A]), revealed no change in the protein content with NR co-treatment, suggesting the improved mitochondrial respiration rates observed are likely related to mitochondrial functional capacity improvements rather than mitochondrial content improvements (Fig 2HL)