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Animal studies have shown that in a rat model of TLE, elevated hippocampal IL-1 levels lead to HPA axis dysfunction and impaired hippocampal-raphe 5-HT pathway function, resulting in depressive-like behaviors (Mazarati et al., 2010)
Serious Adverse Events: Pancreatitis, Thyroid, and Kidney Function Rare but serious side effects include acute pancreatitis (0.1-0.3% in trials), gallbladder issues, and thyroid C-cell tumors in animal models
Anemia improved in the EGCG group because average blood loss significantly decreased from 71 mL/month to 45 mL/month Curcumin: Tsuiji K, Takeda T, Li B, Wakabayashi A, Kondo A, Kimura T, Yaegashi N
& Said, H
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