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We did not find significant differences in the rate of micro- and macrovascular complications between the two groups except for a slightlythough significanthigher prevalence of carotid atherosclerosis in patient prescribed oral semaglutide ( p = 0.013) (data not shown)

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Brown, for example, says she hasnt noticed an increase in GI problems when patients take both medicines, but it is theoretically possible. Side effects often improve over time as your body adjusts, but combining the two could make it harder to tolerate one or both

They mimic the GLP-1 hormone to help you regulate your appetite and cravings