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Some interactions may diminish its effectiveness or cause unwanted side effects

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Coskun and colleagues (Cell Metabolism, 2022) provided the foundational characterisation, demonstrating that balanced engagement of all three receptors produces metabolic effects not achievable through dual or single-receptor pharmacology alone

Sulforaphane ameliorates nonalcoholic fatty liver disease induced by high-fat and high-fructose diet via lps/tlr4 in the gutliver axis