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confirmed that intranasal Semax application induces rapid, gene-specific and region-specific neurotrophin mRNA changes across the rat brain including BDNF upregulation in the hippocampus, brainstem, and cerebellum establishing a comprehensive transcriptional neurotrophin signature that goes beyond a single brain region or gene target

Purification was performed using a two-step purification protocol (Fig

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This extended bioavailability is what makes it useful as a therapeutic peptide