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Knocking out the preproghrelin gene in mice does not seem to affect their size, growth rate, food intake, body composition, and reproduction, indicating that proghrelin products (acyl- or desacyl-ghrelin, obestatin) are not dominantly and critically involved in mouse viability, appetite regulation, and fertility (347), although subtle reductions in the amplitude of secretory GH peaks can be detected in these knockout mice during their youth: these differences recede with aging (348)

It can also help improve bone density, which can help stave off osteoporosis

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Those fluctuations can be compounded by a variety of factors: stress, an imbalanced diet that doesnt prioritize protein, and a lack of focus on strength training