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Microglia with depleted GSH have an exacerbated ROS/RNS production, elevated pro-inflammatory cytokine release, impaired phagocytic clearance, and increased neurotoxic output ( As discussed, the interplay between astrocytes and microglia via modulation of GSH activity implies that GSH is not only a cellular antioxidant, but an important mediator of cross-talk between resident CNS immune cells

If nausea is severe, causes vomiting, or prevents you from eating or drinking for more than a day, contact your doctor

This distinction matters because allergic itching would warrant immediate discontinuation, whereas GLP-1-related itching often resolves with continued use or temporary dose adjustment

Monitoring: Periodic assessment of metabolic markers and subjective response guides dose adjustments