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For negative-mode acquisition, mobile phase A was 100% LCMS-grade H 2 O with 10 mM ammonium acetate, 0.1% ammonium hydroxide and 0.1% medronic acid (Agilent)

Additionally, GLP-1 normally helps slow gastric emptying, enhancing satiety and reducing food intake, but these effects are diminished in diabetic individuals

Upon entering the body, TLK199 undergoes esterase hydrolysis, which releases TLK117, its activated form that has anti-GST activity