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To characterize compound engagement of TGR in adult worms ex vivo, the GSH/GSSG ratio was measured for compounds in Table 1

The additional payments required under section 1833(t)(16)(G) of the Act began on January 1, 2025, based on the policy finalized in the CY 2025 OPPS/ ( ASC final rule with comment period (89 FR 94343 through 94361)

Results of cardiovascular safety studies have not shown any indication of cardiovascular harm, with possible suggestion of cardiovascular benefit

Additionally, Phenylbutazone has excellent bioavailability (up to 90%) 86,88 and long half-life (50-105 hrs) 86 , which may enable dose de-escalation, further decreasing risks