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Mean NADP+ ( A ) and NADPH ( B ) levels in A549shNRF2-BIND-luc cells treated with water (Control) or 2.5 ng/mL doxycycline (Dox) for 48 h

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The study was small and had short follow-up only averaging only 92 days, and patients in the PRP group reported a greater improvement (71%) compared to the needle fenestration group (79%) although this difference didnt reach statistical significance