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The compound shows high enzymatic selectivity, preserves lean mass, and engages longevity-related pathways (e.g., SIRT1), but remains a nonFDA-approved research substance that is WADA-banned and should be used under medical guidance

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Each compound works differently, and understanding their distinctions helps determine whether GHK-Cu should be used as a standalone option or part of a combination protocol

Ethics declarations Conflict of Interest Stephano Cedirian, Monia Donati, Luca Rapparini, Francesca Pampaloni, Michelangelo La Placa, Rossella Sgarzani, Luca Negosanti, Emanuel Raschi and Michela Starace is an Editorial Board member of Dermatology and Therapy