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Platelet intrinsic apoptosis relies on the mitochondrial apoptosome-mediated caspase-9/caspase-3-dependent mechanism, is tightly regulated by Bcl-XL, Bak, and Bax, and lacks the Fas receptor present on erythrocytes [499]

Dysbiosis Gut dysbiosis is defined as the reduction in diversity of GI microflora or depletion of autochthonous or host commensal beneficial bacteria with an enrichment of microbial pathogens that may alter host susceptibility to SARS-CoV-2 infection 235,236

Oxidative stress induces a form of programmed cell death with characteristics of both apoptosis and necrosis in neuronal cells

Research Limitations and Contraindications Certain research models present limitations that must be considered