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Anesthesiology 125:133146 Zhang X, Liu S, MG P, Newport GD, Callicott R, Berridge MS, Apana SM, Jr SW, C W (2013) Protective effects of acetyl l-carnitine on inhalation anesthetic-induced neuronal damage in the nonhuman primate

Based on the challenging measure of mBDNF, an alternative strategy, although not without limitations, could involve measuring total and pro-BDNF levels separately using valid and specific commercial ELISA kits, and then estimating the concentration of mBDNF by calculating the difference (total BDNF minus pro-BDNF levels)

The Polarizable Continuum Model with water was used as the solvent model

And, anecdotally, drinking alcohol also, I'm led to believe.