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If switching from tirzepatide to semaglutide: Take your last dose of tirzepatide as scheduled Wait one week (your normal injection day) Start semaglutide at the initial dose recommended by your provider Follow the prescribed titration schedule Even though youre moving from a dual-agonist to a single GLP-1 agonist, your provider will still start you at the appropriate beginner dose to minimize side effects

Concentrations vary significantly across different tissues and organs

The body also undergoes metabolic changes, prompting the body to produce higher levels of the GLP-1 hormone, which helps to manage blood sugar levels

The dose is increased stepwise according to your response and tolerance: Weeks 58: 0.5 mg weekly Weeks 912: 1.0 mg weekly Weeks 1316: 1.7 mg weekly Week 17 onwards: 2.4 mg weekly (maintenance dose) Your doctor will tailor this schedule to your unique medical history and progress