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Vasodilatory effect Studies showed that GIPR and GLP1R are present in the smooth muscle cells and endothelial arterioles and may have a cardioprotective effect due to endothelium-dependent vasodilation [105]

Leg cramps are not listed as a recognised adverse effect in the UK Summaries of Product Characteristics (SmPCs) for GLP-1 receptor agonists, and evidence for a causal link is limited

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