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Abbreviations DM2: diabetes mellitus type 2 GCR: glucagon receptor GIPR: glucose-dependent insulinotropic peptide receptor GLP-1a: glucagon-like peptide-1 analogues HbA1c: glycated hemoglobin HCC: hepatocellular carcinoma MRI-PDFF: Magnetic Resonance Imaging-Proton Density Fat Fraction NAFLD: Non-alcoholic fatty liver disease NASH: non-alcoholic steatohepatitis NCT: National Clinical Trial number PPAR: Peroxisome Proliferator-Activated Receptor RCT: randomized clinical trial SGLT-2i: sodium-glucose co-transporter-2 inhibitors Declarations Funding None to declare

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Biochim Biophys Acta (BBA)-General Subj

The clinical payoff of this dual mechanism was established in the SURMOUNT-1 trial, a phase 3 randomized, double-blind, placebo-controlled study of 2,539 adults with obesity or overweight without diabetes