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A Phase 2 randomised controlled trial published in the New England Journal of Medicine (Jastreboff et al., 2023) reported mean placebo-adjusted weight reductions of up to approximately 24% over 48 weeks in adults with obesity

This information can support a more informed discussion between patient and provider about whether to pursue Weightwatchers-style behavioral programs, compounded GLP-1 medications, or both

It might be because of fewer platelets made in the bone marrow, more platelets being removed, or because of spleen or liver issues

An increased delivery of fatty acids to skeletal muscle, as well as diminished mitochondrial oxidation, results in increased intracellular content of fatty acid metabolites such as diacylglycerol (DAG), fatty acyl-CoAs, and ceramides