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Stanley CA, Lieu YK, Hsu BYL, Burlina AB, Greenberg CR, Hopwood NJ, et al

The primary active constituents in Lonicera japonica include chlorogenic acid, luteolin, and volatile oils, which collectively confer properties such as heat-clearing and detoxification, antibacterial and antiviral action, anti-inflammatory and swelling-reducing effects, as well as potent antioxidant capabilities

Future research should focus on: Conducting large-scale, randomized controlled trials with rigorous methodological quality

Current clinical management primarily relies on palliative approaches including oral nonsteroidal anti-inflammatory drugs (NSAIDs) and physical therapy, while effective disease-modifying drugs remain unavailable [3, 4]