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Dysfunction in mitochondria can lead to electron leakage in the electron transport chain, resulting in overproduction of ROS such as superoxide anions and hydrogen peroxide ( Endoplasmic reticulum oxidative stress: The endoplasmic reticulum (ER), responsible for protein synthesis and folding, is vulnerable to oxidative stress

If excessive free radicals chronically overwhelm the bodys ability to neutralize them, free radical damage can occur within cells, triggering destructive changes that can lead to degenerative disease and aging (Guo 1999

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