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Molecular Basis of G6PD Deficiency In principle, genetically determined deficiency of G6PD, like that of any other protein, might be attributed either to quantitative changes, such as mutations that affect the amount of the enzyme but not its structure, or to qualitative changes, such as mutations that affect the structure of the enzyme and hence its stability or catalytic efficiency

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Increased GLUD1 activity was further shown to stimulate astrocyte cellular senescence by increasing nucleocytoplasmic -ketoglutarate levels and DNA and histone demethylase activities, increasing proinflammatory gene expression (Sun et al., 2023)