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In it, they discovered a structurally similar compound called exendin-4 , which resists breakdown and binds to the same receptors that GLP-1 does [2]
Tirzepatide targets GLP-1 and GIP, focusing on appetite signaling, glucose regulation, and metabolic efficiency
The nature of these interactions is likely also dependent upon the ability of the CTR ECD to adopt the conformation induced by the bypass motif of Amy-template peptides
Tirzepatide's dual agonist activity at both GIP and GLP-1 receptors introduces additional complexity, as GIP receptor activation may modulate cardiovascular responses differently than GLP-1 alone
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