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In-depth investigation of the mechanism in rats with alcoholic acute pancreatitis via DNA methylation, intestinal flora, and fecal metabolomics

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Intervention studies employing dopaminergic neuron-targeted PGC-1 overexpression via adeno-associated viral vectors reveal enhanced redox homeostasis in striatal neurons and marked attenuation of programmed dopaminergic cell death, establishing this transcriptional coactivators neuroprotective capacity in PD pathophysiology (Wang et al., 2019c)