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Consistently, several studies report that PRP or platelet lysate treatments result in later reductions in MDA/TBARS and increases in SOD/GSH despite early inflammatory activation 50 , 51

While enteral administration offers several advantages over other routes of drug delivery in terms of convenience, promoting medication compliance, it faces several obstacles, of which the most widely recognized are inefficient absorption owing to physical barriers and an acidic microenvironment, along with degradation by proteases and the first-pass metabolism in the liver

A comprehensive biomarker assessmentincluding fasting IGF-1, cortisol, prolactin, and metabolic markerscan help providers identify whether either secretagogue aligns with individual physiology before initiating therapy

Yet, clinicians must balance these potential advantages against any direct electrophysiological effects