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It should be emphasized that although the reduction of GSH/GSSG ratio was at a comparable level in both groups exposed to ethanol, the concentration of 8-OHdG was higher in the group of ethanol-exposed rats with periodontal disease, which proves an addictive effect of this alcohol on gingival oxidative modification and destruction

Future Oncol (2018) 14:92736

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56 However, if the patient continues to present evidence of liver dysfunction beyond persistent ALT elevation (satisfying KCH criteria of acidosis, elevated creatinine, hyperbilirubiniemia, coagulopathy and encephalopathy), then NAC therapy should be continued as these indicators portend a poor prognosis regardless of transaminase levels