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Therefore, although children with various genetic conditions and neurodevelopmental disorders usually have normal GH secretion as assessed by the classical criteria for diagnosing GH deficiency (155), altered IGF-1 levels or actions in the various compartments of the central nervous system of these patients can significantly influence brain development and function

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In HFD-fed mice, the treatment demonstrated improvements in glucose tolerance, reduced hepatic steatosis, and alleviated adipose inflammation, partially by restoring oxidative stress, inflammation, and ERSrelated gene expression through SIRT1 (Yoshino et al

However, the results may depend on genetic factors and more research is needed