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As you lose weight, your basal metabolic rate (the calories you burn at rest) may decrease, and your body may adjust by becoming more efficient with energya phenomenon known as adaptive thermogenesis

Increases in sympathetic outflow remain the largest safety concern for melanocortin agonists after compounds such as LY2112688 and bremelanotide demonstrated increases in both blood pressure and heart rate in clinical trials (16, 150)

If theyre still stumped, they may recommend additional testing to rule out other causes

The gap between expectation and outcome prompted a sharp decline in Novo Nordisks share price when the results were announced and opened questions about whether CagriSema could differentiate itself sufficiently from existing approved therapies