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Regarding the priority of testable mechanisms at this stage, the SCFAsmodule (specifically butyrate) commands a relatively higher verification priority due to the existence of closed-loop clues involving ABX depletion effect + FMT transferability + Metabolite rescue. Conversely, bile acids/tryptophan and multi-metabolic pathway reprogramming are better suited as a pool of candidate mechanisms, still requiring convergence to the level of key molecules and receptors/pathways through Supplementation/Blocking shortest closed-loop experiments

HPO, hypothalamicpituitaryovarian axis

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Diabetes Care 21 , 14141431 (1998)