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The 'superpotent' designation originates from the foundational work by Hadley, Hruby, and colleagues at the University of Arizona in the late 1980s, who demonstrated that Melanotan II induced melanin dispersion in frog (Rana pipiens and Anolis carolinensis) skin bioassays at concentrations 100-1000 fold lower than the native alpha-MSH hormone

Supplementary material The Supplementary Material for this article can be found online at: References 1 ChenJ.WangM.JoyceA.DeFrancoD.KavosiM.XuX.et al (2014)

This triple mechanism showed higher average weight loss in early clinical trials

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