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When testing each drug type separately, we estimate the effect of the SNP on BMI % to be larger in tirzepatide (effect = 0.95%) than semaglutide (effect = 0.51%), although the 95% confidence intervals were overlapping (Extended Data Fig

29 Of particular interest is the finding that opiorphin is significantly reduced (4.7 1.0 ng/mL, n = 4) in semen of patients with congenital bilateral absence of the vas deferens (CBAVD), a medical condition associated with anomalies of the vas deferens and seminal vesicle

Recent studies, however, have linked these medications to additional benefits, such as a reduction in heart disease and dementia risk, as doctors recommend them to a growing number of patients