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6 Conclusion and outlook Depression is a prevalent mental disorder characterized by persistent symptoms such as low mood and reduced interest, with severe cases sometimes leading to suicidal tendencies, and has been a major contributor to poor global health and disability, with a recently increasing incidence (ZHANG X

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Mitapivat markedly reduced erythrophagocytosis in spleens of 4.2 / mice when compared with 4.2 / controls (Figure 4B)

We hypothesize that GABA exerts its effects by modulating gut microbiota, reducing oxidative stress in the striatum, and restoring the GABA-glutamate metabolic balance