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Among them, taurodeoxycholate and taurochenodeoxycholate were involved in the metabolic enrichment pathway of bile acid biosynthesis ( p = 0.035) (Table 2)

Clinical and preclinical studies show that, in addition to cases of hepatic encephalopathy, liver dysfunction is implicated in increasing the susceptibility to Alzheimers disease, the leading cause of dementia, through yet elucidated mechanisms 74,75,76

Hyperarousal in insomnia disorder: Current evidence and potential mechanisms