The number of observations and statistical tests used are stated in the figure legends
the body cant synthesize them endogenously

Ingredients: Water, Butylene Glycol, Caprylic/Capric Triglyceride, Beeswax, Niacinamide, Cetearyl Alcohol, Isononyl Isononanoate, Arachidyl Alcohol, 1,2-Hexanediol, Polyglyceryl-3 Methylglucose Distearate, Behenyl Alcohol, Glyceryl Stearate, Betaine, Simethicone, Arachidyl Glucoside, Cetearyl Olivate, Arginine, Carbomer, Sorbitan Olivate, Allantoin, Glycerin, Panthenol, Tocopherol, Xanthan Gum, Glutathione (600 ppm), Dipotassium Glycyrrhizate, Ethylhexylglycerin, Disodium EDTA, Sodium Hyaluronate, Glucose, Alcohol, Malva Sylvestris (Mallow) Extract, Melissa Officinalis Leaf Extract, Alchemilla Vulgaris Extract, Achillea Millefolium Extract, Veronica Officinalis Extract, Mentha Piperita (Peppermint) Leaf Extract, Primula Veris Extract, Lycopodium Clavatum Extract, Equisetum Arvense Extract, Ceramide NP, Hydrogenated Lecithin, Polyglyceryl-10 Stearate, Sodium Hydroxide, Sodium Ascorbyl Phosphate, Biotin, Folic Acid, Pyridoxine, Cyanocobalamin, Linoleic Acid, Riboflavin, Beta-Carotene, Thiamine HCl, Copper Tripeptide-1, Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Fragrance

Provided that the sourcing is of high quality (look for testing of heavy metals and other third-party testing and validation), the bulk of data point to the value of getting at least 1g of EPA per day from fish oil supplement or food to improve mood, blood profiles, and lower inflammation which indirectly support numerous aspects of brain and body health