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In each context, bioenergetic failure, oxidative stress, disrupted mitochondrial dynamics, and defective quality control converge to amplify neuronal vulnerability and drive disease progression

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Supplementary Tables 9 ): a first DMR in the 3 region of Growth Differentiation Factor 7 ( GDF7 ) gene on chromosome 2, containing 9 CpGs located in the 3-part of the gene, and 8 of which cover a CpG island (CGI) ( Figure 4B , Supplementary Figure 5