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Chronic hyperglycemia-induced ROS overproduction, primarily derived from mitochondrial ETC leakage and NOX activation, leads to eNOS uncoupling due to BH4 oxidation, reducing NO bioavailability and impairing vasodilation (Giacco and Brownlee, 2010)

Together, they cover more of the biological terrain that menopause disrupts than either can alone

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GLP-1 (glucagon-like peptide-1) receptor agonists, such as semaglutide (Ozempic, Wegovy) or liraglutide (Saxenda), are medications originally developed for diabetes management but are also used for weight loss