Carriers of the UGT1A4*3 variant can experience reduced therapeutic efficacy due to ultrarapid glucuronidation, thus higher doses of some UGT1A4 substrates may be required for people carrying the UGT1A4*3 variant, such as seen during posaconazole treatment as an antifungal prophylaxis during treatment of hematological malignancies
The fact that the highest cholesterol occupancy residues identified correspond to either ring-containing (Phe) or branched (Val, Leu, Ile) amino acids suggests that these residue types might play important roles in cholesterol stabilisation at GLP-1R binding pockets
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