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Serious but uncommon side effects of semaglutide include pancreatitis, gallbladder disease (including gallstones and gallbladder inflammation), acute kidney injury, worsening diabetic retinopathy in people with existing eye disease, hypoglycemia when used with insulin or sulfonylureas, and severe allergic reactions such as anaphylaxis or angioedema

These changes, including the improved regulation of blood sugar levels, may temporarily impact your energy levels, causing fatigue

For a 220-pound person, that translates to roughly 4.4 to 8.4 pounds

Moreover, technical hurdles for generics, including peptide stability and device compatibility, persist, potentially delaying full market saturation beyond January 2026