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Decreased total antioxidant capacity and elevated lipid hydroperoxide concentrations in sera of epileptic patients receiving phenytoin

Haffner D, Schaefer F, Girard J, et al

To gain further insight into matrix H 2 O 2 handling in general and more specifically into possible mechanisms of H 2 O 2 mediated toxicity, we employed genetically encoded probes that enable subcellular compartmentspecific measurement of H 2 O 2 , the glutathione redox potential ( E GSH ), and Prx1 oxidation, together with biochemical assessment of cysteine redox states, transcriptome analyses and cell death assays