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Targeted inhibition of microbial choline-TMAO conversion was also evaluated in a pressure overload mice model of heart failure, where it improved cardiac remodeling and cardiac function

Given the strength of these preliminary signals, the field must now shift focus toward conducting well-powered phase 3 RCTs to validate these associations

A superior molecule with the same evidence base If a next-generation regenerative active emerged with comparable safety, broader mechanism evidence, and better intrinsic delivery, the focus would shift

They are used together in laboratory settings under appropriate research protocols, but this does not indicate approval for human or animal use