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The mechanism of action has not changed, only the addition of a nausea-dampening cofactor that may make the critical early weeks and dose escalation phases manageable

The lowest therapeutic dose is 0.25 mg weekly, and while this is typically used as a starting dose, some people maintain this amount throughout their treatment with great success

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Hyperglycemia aggravates atrial interstitial fibrosis, ionic remodeling and vulnerability to atrial fibrillation in diabetic rabbits