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It is well known that HFD-induced obesity promotes low-grade hypothalamic inflammation, causing deregulation of central mechanisms that control energy homeostasis 59 , and both physical exercise and some pharmacotherapies have been shown to improve systemic metabolism by attenuating hypothalamic inflammation 60,61

Farnesoid X receptor responds to bile acids and represses cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription

These studies suggest that lipid accumulation by an uncoupled Gro3P shuttle contributes to kidney cancers and heart dysfunction in metabolic disorders

Even without overt toxicity, the sensory unpleasantness alone is sufficient to maintain aversion across dozens of exposures