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However, the symptomatic overlap means that patients with IBS may find it challenging to distinguish between their baseline condition and medication-related side effects

doi: 10.1042/bj2660235 46 MarkwardtKLMagninoPEPangIH

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Rats were acclimated for five days and randomly assigned to their respective treatment groups, housed in polycarbonate (PC) cages (identified with dates, number of study, group, dose, number and sex of each animal) at 2024 C, with a relative humidity of 4070% and noise level of 60 dB, illumination 12 h per day (fluorescent lighting), a standard good laboratory practice (GLP) diet and fresh water ad libitum