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Although affinity-based screening technologies such as phage and yeast display enable the high-throughput screening of large combinatorial peptide libraries, they rely on the use of recombinant protein or membrane preparations and do not distinguish between agonists, inverse agonists and antagonists

They tracked which nerve cells were activated by the drug and were then able to stimulate these cells without administering the drug itself

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Finally, although bariatric surgery is currently the most effective therapy to achieve weight loss in patients with very severe obesity, its use in patients with PWS remains still controversial [24]