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In severe acute infections, this systemic consumption can completely drain the body's antioxidant reserves

The imidazole nitrogen of the histidine side chain donates one of the three nitrogen ligands to the copper, and the position of histidine at the second residue is what enables the deprotonated amide nitrogen of the preceding Gly-His peptide bond to also coordinate the copper

Accessibility, Cost, and Ease of Use Hydrogen water is accessible via infusers or bottles ($50-$500 for equipment or $2-$5 per bottle), easy to use daily, and considered safe as a natural option

The FDA emphasizes that many cases result from unintentional overdoses due to multiple over-the-counter medications containing acetaminophen