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43 One RCT evaluated B12 alongside anti-depressants in patients with depression and moderately low B12 status (190300 ng/l) and found that 100% of those on B12, 1000 g per week i.m

MTHFR Mutations and B Vitamin Deficiencies April 29, 2022 People with a certain MTHFR gene mutation (C677T) may be more likely to develop B vitamin deficiencies

This helps researchers move from compound-specific review into broader pathway comparison without leaving the core research archive

This represents a significant gap between regulatory approval for safety (as a food substance) and clinical efficacy (which is absent or insufficient for weight loss)