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Side effects at the 12 mg level roughly doubled

Yadav and Colleagues demonstrated that supplementing a high-fat diet with a highly concentrated probiotic (VSL#3) reduced the abundance of Firmicutes and increased Bifidobacteria and Bacteroidetes

The index date was the day of first refill of a study drug

mRNA therapeutics require lipid nanoparticle (LNP) formulation capability, with the Moderna and BioNTech/Pfizer vaccine programs having demonstrated that LNP encapsulation is technically demanding, IP-rich (Arbutus Biopharma and Genevant Sciences control key ionizable lipid patents that were the subject of litigation with Moderna), and sensitive to process parameters that affect particle size, encapsulation efficiency, and in vivo transfection activity